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However, following multiple overdoses which is the predominant mode of paediatric overdose has been reported [15, 51, 56,57,58]

We believe the estimated burden for both patient screening and data submission would be the same for PCHs

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DEG analysis of early-stage tumor cells showed that, compared to low- and high-mutant tumor cells, moderate-mutant tumor cells significantly upregulated genes encoding cytosolic ribosomal proteins (RPL and RPS), mitochondrial ribosomal proteins (MRPL and MRPS), and OXPHOS-related proteins (Fig